Molecular interaction of dihydropyridine receptors with type-1 ryanodine receptors in rat brain
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منابع مشابه
Molecular interaction of dihydropyridine receptors with type-1 ryanodine receptors in rat brain.
In striated muscles, Ca2+ release from internal stores through ryanodine receptor (RyR) channels is triggered by functional coupling to voltage-activated Ca2+ channels known as dihydropyridine receptors (DHPRs) located in the plasma membrane. In skeletal muscle, this occurs by a direct conformational link between the tissue-specific DHPR (Ca(v)1.1) and RyR(1), whereas in the heart the signal is...
متن کاملDihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals.
Ca2+ stores were studied in a preparation of freshly dissociated terminals from hypothalamic magnocellular neurons. Depolarization from a holding level of -80 mV in the absence of extracellular Ca2+ elicited Ca2+ release from intraterminal stores, a ryanodine-sensitive process designated as voltage-induced Ca2+ release (VICaR). The release took one of two forms: an increase in the frequency but...
متن کاملDihydropyridine Receptors and Type 1 Ryanodine Receptors Constitute the Molecular Machinery for Voltage-Induced Ca Release in Nerve Terminals
Valérie De Crescenzo,1 Kevin E. Fogarty,1,3 Ronghua ZhuGe,1,3 Richard A. Tuft,1,3 Lawrence M. Lifshitz,1,3 Jeffrey Carmichael,3 Karl D. Bellvé,1,3 Stephen P. Baker,2 S. Zissimopoulos,4 F. Anthony Lai,4 José R. Lemos,1 and John V. Walsh Jr1 1Department of Physiology and 2Information Services Bioinformatics Unit, University of Massachusetts Medical School, Worcester, Massachusetts 01655, 3Biomedi...
متن کاملBi-directional coupling between dihydropyridine receptors and ryanodine receptors.
The control of calcium signaling between plasma membrane dihydropyridine receptors (DHPRs or L-type calcium channels) and ryanodine receptors (RyRs or calcium release channels) located in the endoplasmic/sarcoplasmic reticulum (ER/SR) underlies a broad array of functions including skeletal muscle contraction, cardiac performance, arteriole tone, neurosecretion, synaptic plasticity, and gene reg...
متن کاملExpression of Dihydropyridine and Ryanodine Receptors in Type IIA Fibers of Rat Skeletal Muscle
In this study, the fiber type specificity of dihydropyridine receptors (DHPRs) and ryanodine receptors (RyRs) in different rat limb muscles was investigated. Western blot and histochemical analyses provided for the first time evidence that the expression of both receptors correlates to a specific myosin heavy chain (MHC) composition. We observed a significant (p=0.01) correlation between DHP as...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2001
ISSN: 0264-6021
DOI: 10.1042/0264-6021:3540597